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Weight-loss benefits
Large, clinically meaningful weight reduction: Early-phase trials report higher average weight loss than dual GLP‑1/GIP agonists (e.g., tirzepatide), with many participants reaching 15–20%+ body weight loss over several months.
Fast onset of effect: Weight loss often begins within the first few weeks and continues steadily with dose escalation.
Strong appetite suppression: Reduced hunger, fewer cravings, and lower desire for high-calorie foods, leading to sustained calorie reduction.
Fat loss with muscle preservation: When protein intake and resistance training are maintained, loss is predominantly fat, helping preserve lean mass.
Health benefits
Metabolic improvements: Lower fasting glucose and HbA1c, improved insulin sensitivity, and better post-meal glucose control.
Cardiovascular risk factors: Reductions in blood pressure, triglycerides, and LDL cholesterol; improved overall lipid profile.
Liver benefits: Decreased liver fat and improvements in markers associated with metabolic dysfunction–associated steatotic liver disease (MASLD).
Inflammation: Lower systemic inflammation markers (e.g., CRP) in trial settings.
Sleep apnea: Weight loss often reduces obstructive sleep apnea severity.